1373405-39-0

Basic information

• Product Name: C₂₀H₁₈O₈*C₂₀H₂₁FN₂O
• CAS NO: 1373405-39-0
• Molecular Weight: 710.756
• Mol File: 1373405-39-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₈O₈*C₂₀H₂₁FN₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₈O₈*C₂₀H₂₁FN₂O(1373405-39-0)
• EPA Substance Registry System: C₂₀H₁₈O₈*C₂₀H₂₁FN₂O(1373405-39-0)

Safety Data

• Hazardous Substances Data: 1373405-39-0(Hazardous Substances Data)

Upstream product

• 32634-66-5 Di-p-toluoyl-L-tartaric acid 
• 59729-32-7 citalopram hydrobromide 

Relevant articles and documents

Resolution of a diasteromeric salt of citalopram by multistage crystallization

Multistage crystallization has been used for resolution of the racemic mixture of citalopram to obtain pure S-citalopram. The racemate was converted to a diasteromeric salt pair using (+)-O,O′-di-p-toluoyl-d-tartaric acid, (+)DTT, as a resolving agent. The obtained salts involved solid solutions almost within the entire range of the crystalline phase composition, which excluded the possibility of a single-stage resolution. Therefore, a multistep crystallization technique was employed that allowed enrichment of the racemate with the desired diastereomer in the liquid phase. Moreover, a procedure for restoring the 1:1 composition of the depleted solid phase has been developed. The procedure was based on formation of a diasteromeric salt pair with the opposite enantiomer of the resolving agent, i.e., (-)DTT.