1373440-40-4

Upstream product

• 1240163-16-9 (1R,3S)-2-(benzyloxycarbonyl)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 

Downstream Products

• 1373440-41-5 benzyl (1R,3S)-3-carbamothioyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate 
• 1373440-42-6 benzyl (1R,3S)-6,7-dimethoxy-1-phenyl-3-(4-phenyl-1,3-thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate 
• 1352834-57-1 2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)-4-phenylthiazole 
• 1373440-46-0 4-tert-butyl-2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)thiazole 

Relevant academic research and scientific papers

Comparison of tetrahydroisoquinoline (TIQ) thiazole and oxazoline ligands for asymmetric Henry reactions

A series of novel C1 symmetric thiazole ligands with a tetrahydroisoquinoline (TIQ) backbone were synthesized. Their application in the catalytic asymmetric Henry reaction was investigated with comparison to a corresponding TIQ oxazoline ligand. The Cu(II)-oxazoline complex was more reactive and furnished moderate enantioselectivities up to 61:36 (syn:anti) with 75:25 diastereomeric excess, while the Cu(II)-thiazole complexes had lower selectivity. This is the first example where a direct comparison between an N, N-type thiazole and oxazoline ligands has been studied.