1373440-45-9Relevant academic research and scientific papers
Comparison of tetrahydroisoquinoline (TIQ) thiazole and oxazoline ligands for asymmetric Henry reactions
Pawar, Sunayna S.,Chakka, Sai Kumar,Andersson, Pher G.,Kruger, Hendrik G.,Maguire, Glenn E.M.,Govender, Thavendran
, p. 23 - 29 (2012/06/01)
A series of novel C1 symmetric thiazole ligands with a tetrahydroisoquinoline (TIQ) backbone were synthesized. Their application in the catalytic asymmetric Henry reaction was investigated with comparison to a corresponding TIQ oxazoline ligand. The Cu(II)-oxazoline complex was more reactive and furnished moderate enantioselectivities up to 61:36 (syn:anti) with 75:25 diastereomeric excess, while the Cu(II)-thiazole complexes had lower selectivity. This is the first example where a direct comparison between an N, N-type thiazole and oxazoline ligands has been studied.
