1373441-20-3Relevant academic research and scientific papers
Site-selective catalysis: Toward a regiodivergent resolution of 1,2-diols
Worthy, Amanda D.,Sun, Xixi,Tan, Kian L.
, p. 7321 - 7324 (2012)
This paper demonstrates that the secondary hydroxyl can be functionalized in preference to the primary hydroxyl of a 1,2-diol. The site selectivity is achieved by using an enantioselective organic catalyst that is able to bond to the diol reversibly and covalently. The reaction has been parlayed into a divergent kinetic resolution on a racemic mixture, providing access to highly enantioenriched secondary-protected 1,2-diols in a single synthetic step.
