137348-11-9

Basic information

• Product Name: SUBSTANCE P ACETATE SALT HYDRATE, BIOCHEMIKA
• Synonyms: SUBSTANCE P ACETATE SALT HYDRATE, BIOCHEMIKA;SUBSTANCE P ACETATE SALT HYDRATE;Substance P hydrate acetate salt
• CAS NO: 137348-11-9
• Molecular Formula: 3C₂H₄O₂*C₆₃H₉₈N₁₈O₁₃S
• Molecular Weight: 1407.7
• EINECS: 251-545-8
• Product Categories: AgonistPeptides for Cell Biology;TachykininsObesity Research;Neuropeptides;Neurotransmission (Obesity);Peptides for Cell Biology;Tachykinins
• Mol File: 137348-11-9.mol
• Article Data: 2

Chemical Properties

• Appearance: white/
• Storage Temp.: −20°C
• Solubility: 0.1 M acetic acid: soluble1mg/mL
• BRN: 5153552
• CAS DataBase Reference: SUBSTANCE P ACETATE SALT HYDRATE, BIOCHEMIKA(CAS DataBase Reference)
• NIST Chemistry Reference: SUBSTANCE P ACETATE SALT HYDRATE, BIOCHEMIKA(137348-11-9)
• EPA Substance Registry System: SUBSTANCE P ACETATE SALT HYDRATE, BIOCHEMIKA(137348-11-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 137348-11-9(Hazardous Substances Data)

Usage

Uses

Substance P acetate salt hydrate has been:used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in miceadministered in central nucleus (ACE) in rat to study its positive reinforcing effectsused as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat

General Description

Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.

Biochem/physiol Actions

NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents.

Upstream product

• 42001-61-6 Z-Arg(NO₂)-Pro-Lys(Z)-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂ 

Relevant articles and documents

Solid Phase Synthesis of Substance P and Its Analogues Employing 9-Fluorenylmethoxycarbonylamino Acid Active Esters

Substance P and six of its analogues containing D-p-hydroxyphenylglycine at positions 7 and/or 8 have been synthesized employing fluorenylmethoxycarbonylamino acid (Fmoc) active esters and p-alkoxybenzyl alcohol resin.Diethylamine is employed for the cleavage of Fmoc-group.The agonistic and antagonistic activities of the peptides have been studied.