137348-11-9 Usage
Uses
Used in Neuroscience Research:
Substance P Acetate Salt Hydrate, BioChemika, is used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in mice, aiding in the study of pain perception and related neurological processes.
Used in Behavioral Neuroscience:
In the central nucleus (ACE) of rats, Substance P Acetate Salt Hydrate, BioChemika, is administered to study its positive reinforcing effects, which can provide insights into the neurochemical basis of addiction and reward mechanisms.
Used in Cellular and Molecular Biology:
Substance P Acetate Salt Hydrate, BioChemika, is used as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rats. This application helps researchers understand the role of Substance P in the regulation of vascular tone and lymphatic function, which can be crucial for developing targeted therapies for various conditions.
Biochem/physiol Actions
NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents.
Check Digit Verification of cas no
The CAS Registry Mumber 137348-11-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,3,4 and 8 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 137348-11:
(8*1)+(7*3)+(6*7)+(5*3)+(4*4)+(3*8)+(2*1)+(1*1)=129
129 % 10 = 9
So 137348-11-9 is a valid CAS Registry Number.
137348-11-9Relevant academic research and scientific papers
Solid Phase Synthesis of Substance P and Its Analogues Employing 9-Fluorenylmethoxycarbonylamino Acid Active Esters
Sivanandaiah, K. M.,Rangaraju, N. S.
, p. 1045 - 1049 (2007/10/02)
Substance P and six of its analogues containing D-p-hydroxyphenylglycine at positions 7 and/or 8 have been synthesized employing fluorenylmethoxycarbonylamino acid (Fmoc) active esters and p-alkoxybenzyl alcohol resin.Diethylamine is employed for the cleavage of Fmoc-group.The agonistic and antagonistic activities of the peptides have been studied.
Catalytic Transfer Hydrogenation in Synthesis of Substance P
Sivanandaiah, K. M.,Rangaraju, N. S.
, p. 787 - 792 (2007/10/02)
The utility of catalytic transfer hydrogenation (CTH) in the synthesis of longer peptides has been demonstrated by the stepwise synthesis of Substance P in the solution phase.The technique of CTH using formic acid as a hydrogen donor provides a facile method for the removal of protecting groups such as benzyloxycarbonyl and nitro in the synthesis of medium-sized peptides also.Except in the case of glutaminyl peptides where the purity and yield are affected to some extent by cyclization, the products are generally pure requiring minimum purification and the yields are good.
