1373496-75-3Relevant academic research and scientific papers
A 1,4-diphenyl-1,2,3-triazole-based β-turn mimic constructed by click chemistry
Wu, Chun-Fang,Zhao, Xin,Lan, Wen-Xian,Cao, Chunyang,Liu, Jin-Tao,Jiang, Xi-Kui,Li, Zhan-Ting
, p. 4261 - 4270 (2012/06/18)
A series of 1,4-diphenyl-1,2,3-triazole-incorporated amide derivatives have been designed and prepared. X-ray crystallographic and (1D and 2D) 1H NMR studies reveal that these compounds fold into stable U-shaped conformations driven by three-center intramolecular C-H???O hydrogen-bonding formed between the triazole C-5 H atom and the two ether O atoms. Such folded structures make this 1,4-diphenyl-1,2,3-triazole skeleton a good candidate to be used as β-turn mimic. To prove this, the formation of a β-hairpin structure induced by this β-turn motif has been further demonstrated.
