137350-78-8

Basic information

• Product Name: 2-(3-hydroxy-4-methoxyphenyl)-benzo[d]thiazole
• Synonyms: 2-(3-hydroxy-4-methoxyphenyl)-benzo[d]thiazole
• CAS NO: 137350-78-8
• Molecular Weight: 257.313
• Mol File: 137350-78-8.mol

Chemical Properties

• CAS DataBase Reference: 2-(3-hydroxy-4-methoxyphenyl)-benzo[d]thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-hydroxy-4-methoxyphenyl)-benzo[d]thiazole(137350-78-8)
• EPA Substance Registry System: 2-(3-hydroxy-4-methoxyphenyl)-benzo[d]thiazole(137350-78-8)

Safety Data

• Hazardous Substances Data: 137350-78-8(Hazardous Substances Data)

Upstream product

• 621-59-0 isovanillin 
• 137-07-5 2-amino-benzenethiol 

Downstream Products

• 1632028-76-2 3-(4-nitrophenyl)methyl-2-(3-hydroxy-4-methoxyphenyl)benzothiazol-3-ium bromide 

Relevant articles and documents

Design, synthesis and evaluation of benzothiazole derivatives as multifunctional agents

Oxidative stress is the product or aetiology of various multifactorial diseases; on the other hand, the development of multifunctional compounds is a recognized strategy for the control of complex diseases. To this end, a series of benzothiazole derivatives was synthesized and evaluated for their multifunctional effectiveness as antioxidant, sunscreen (filter), antifungal and antiproliferative agents. Compounds were easily synthesized via condensation reaction between 2-aminothiophenols and different benzaldehydes. SAR study, particularly in position 2 and 6 of benzothiazoles, led to the identification of 4g and 4k as very interesting potential compounds for the design of multifunctional drugs. In particular, compound 4g is the best blocker of hERG potassium channels expressed in HEK 293 cells exhibiting 60.32percent inhibition with IC50 = 4.79 μM.

Synthesis and biological activity of hydroxy substituted phenyl-benzo[d]thiazole analogues for antityrosinase activity in B16 cells

In this study, we synthesized hydroxy and/or alkoxy substituted phenyl-benzo[d]thiazole derivatives using substituted benzaldehydes and 2-aminothiophenol in MeOH. The structures of these compounds were established by 1H and 13C NMR a

NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR

Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.