1373520-33-2Relevant academic research and scientific papers
Asymmetric phase-transfer-catalyzed conjugate addition of glycine imine to exocyclic α,β-unsaturated ketones: Construction of polycyclic imines containing three stereocenters
Nie, Jing,Hua, Ming-Qing,Xiong, Heng-Ying,Zheng, Yan,Ma, Jun-An
scheme or table, p. 4209 - 4216 (2012/06/18)
We developed a facile, one-pot, multistep transformation between glycine imine and exocyclic α,β-unsaturated ketones in reactions catalyzed by chiral phase-transfer catalysts (PTC). A series of polycyclic imines containing three adjacent stereocenters were obtained in good to high yields with high diastereo- and enantioselectivities. Further transformation of the imines could afford N-fused polycyclic compounds with four adjacent stereocenters.
