Cas 1373522-71-4,4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)phenyl)morpholine

1373522-71-4

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Basic information

Product Name: 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)phenyl)morpholine
Synonyms: 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)phenyl)morpholine
CAS NO:1373522-71-4
Molecular Formula:
Molecular Weight: 357.181
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)phenyl)morpholine(CAS DataBase Reference)
NIST Chemistry Reference: 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)phenyl)morpholine(1373522-71-4)
EPA Substance Registry System: 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)phenyl)morpholine(1373522-71-4)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1373522-71-4(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1373522-71-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,3,5,2 and 2 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1373522-71:
(9*1)+(8*3)+(7*7)+(6*3)+(5*5)+(4*2)+(3*2)+(2*7)+(1*1)=154
154 % 10 = 4
So 1373522-71-4 is a valid CAS Registry Number.

1373522-71-4Upstream product

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1373522-71-4Relevant academic research and scientific papers

HETEROARYL SYK INHIBITORS

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Page/Page column 46; 47; 48, (2015/11/10)

The invention relates to new substituted heteroarylsof formula (1) wherein A is selected from the group consisting of N and CH, D is selected from the group consisting of S and O, E is C, T is C, G is C, and wherein each of the broken (dotted) double bonds in ring 1 are selected from either a single bond or a double bond under the proviso that all single and double bonds of ring 1 are arranged in such a way that they all form together with ring 2 an aromatic ring system, and wherein R1, M and R3 are defined according to claim 1, and to the above compounds for the treatment of a disease selected from the group consisting of asthma, COPD, allergic rhinitis, allergic dermatitis, lupus erythematodes, lupus nephritis and rheumatoid arthritis.

Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P1)

Ren, Feng,Deng, Guanghui,Wang, Hailong,Luan, Linbo,Meng, Qinghua,Xu, Qiongfeng,Xu, Heng,Xu, Xuesong,Zhang, Haibo,Zhao, Baowei,Li, Chengyong,Guo, Taylor B.,Yang, Jiansong,Zhang, Wei,Zhao, Yonggang,Jia, Qiantao,Lu, Hongtao,Xiang, Jia-Ning,Elliott, John D.,Lin, Xichen

supporting information; experimental part, p. 4286 - 4296 (2012/07/03)

A novel series of 1,2,4-thiadiazole compounds was discovered as selective S1P1 agonists. The extensive structure-activity relationship studies for these analogues were reported. Among them, 17g was identified to show high in vitro potency with reasonable free unbound fraction in plasma (Fu > 0.5%), good brain penetration (BBR > 0.5), and desirable pharmacokinetic properties in mouse and rat. Oral administration of 1 mg/kg 17g resulted in significant peripheral lymphocytes reduction at 4 h after dose and rapid lymphocytes recovery at 24 h. 17g showed a transient lymphopenia profile in the repeated dose study in mouse. In addition, 17g also demonstrated efficacy comparable to that of FTY720 (1) in the mouse EAE model of MS.

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