1373760-88-3

Basic information

• Product Name: 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[1-(4-ter-butylbenzyl)-1H-1,2,3-triazol-4-yl]-2-propanol
• CAS NO: 1373760-88-3
• Molecular Weight: 452.507
• Mol File: 1373760-88-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[1-(4-ter-butylbenzyl)-1H-1,2,3-triazol-4-yl]-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[1-(4-ter-butylbenzyl)-1H-1,2,3-triazol-4-yl]-2-propanol(1373760-88-3)
• EPA Substance Registry System: 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[1-(4-ter-butylbenzyl)-1H-1,2,3-triazol-4-yl]-2-propanol(1373760-88-3)

Safety Data

• Hazardous Substances Data: 1373760-88-3(Hazardous Substances Data)

Upstream product

• 86404-63-9 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone 
• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 
• 372-18-9 1,3-Difluorobenzene 
• 917078-24-1 2?(2,4?difluorophenyl)?1?(1H?1,2,4?triazol?1?yl)pent?4?yn?2?ol 
• 18880-00-7 1-(bromomethyl)-4-(1,1-dimethylethyl)benzene 

Relevant articles and documents

New triazole derivatives as antifungal agents: Synthesis via click reaction, in vitro evaluation and molecular docking studies

A series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-substituted- 2-propanols (5a-5y) which are analogues of fluconazole, have been designed and synthesized via Cu(I)-catalyzed azide-alkyne cycloaddition on the basis of computational docking experiments to the active site of the cytochrome P450 14α-demethylase (CYP51). The in vitro antifungal activities of all the target compounds were evaluated against eight human pathogenic fungi. Compound 5l showed the best antifungal activities.