137378-19-9Relevant academic research and scientific papers
Synthesis of chemically and functionally diverse scaffolds from pentaerythritol
Hanessian, Stephen,Prabhanjan, Hubli,Qiu, Dongxu,Nambiar, Sudhir
, p. 1731 - 1737 (2007/10/03)
Pentaerythritol (2,2-bis-hydroxymethyl-propane-1,3-diol) was converted into a series of mono-, di-, and trisubstituted derivatives, comprising allyl ethers and amino-alkyl ethers, by systematic chemical manipulation of the hydroxy groups. The remaining hydroxymethyl group in the case of the trisubstituted analog was functionalized with ether groups bearing terminal ω-carboxyl or ω-alkene groups. These derivatives are versatile templates and scaffolds for single, double, or triple substitution with appropriate ligands forming amides and esters, and allowing the attachment of the ω-alkene or ω-carboxyl group to solid support for combinatorial chemistry.
Synthesis of Benzo-13-crown-4 Derivatives
Czech, Bronislaw P.,Zazulak, Wolodymyr,Kumar, Anand,Dalley, N. Kent,Weiming, Jiang,Bartsch, Richard A.
, p. 1387 - 1394 (2007/10/02)
A series of nine, new benzo-13-crown-4 compounds which bear one or two substituents on the three-carbon bridge has been prepared in good yields by cesium fluoride-assisted cyclization reactions of catechol with ditosylates of the appropriate glycols.The solid state structure of 9,9-dibenzyl-2,3-benzo-13-crown-4 is determined and compared with the reported structure for the unsubstituted crown ether.
