1373820-97-3

Upstream product

• 2591-86-8 N-Formylpiperidine 
• 90-02-8 salicylaldehyde 
• 1373821-09-0 2-formylphenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 17336-68-4 N'-(2-methoxy-1-phenylethylidene)-4-methylbenzenesulfonohydrazide 

Downstream Products

• 1443464-27-4 2-methoxy-3-phenyl-1H-inden-1-one (1Z)-2-phenylhydrazone 
• 92439-00-4 4-phenyl-1H-2-benzopyran-1-one 

Relevant academic research and scientific papers

Synthesis of 3-aryl-2-methoxyinden-1-one (Z)-phenylhydrazones via hydrobromic acid-mediated cyclization of 2-(1-aryl-2-methoxyethenyl)benzaldehyde phenylhydrazones

2-(1-Aryl-2-methoxyethenyl)benzaldehydes 2, obtained by successive treatment of 1-(1-aryl-2-methoxyethenyl)-2-bromobenzenes 1 with BuLi and 1-formylpiperidine, were transformed to the corresponding phenylhydrazones 3 on treatment with PhNHNH2.

Synthesis of 4-arylisocoumarins (=4-aryl-1H-2-benzopyran-1-ones) through acidic hydrolysis of (Z)-2-(1-aryl-2-methoxyethenyl)benzaldehydes, followed by oxidation

4-Arylisocoumarins (=4-aryl-1H-2-benzopyran-1-ones) 6 were prepared from 2-(1-aryl-2-methoxyethenyl)-1-bromobenzenes 1. Successive treatment of these bromo styrenes with BuLi and 1-formylpiperidine gave a mixture of (E)- and (Z)-2-(1-aryl-2-methoxyethenyl)benzaldehydes 2. Hydrolysis of (Z)-isomers with conc. HBr, followed by pyridinium chlorochromate (PCC) oxidation of the resulting 1H-2-benzopyran-1-ol derivatives 4 (and 5), afforded the desired products. Copyright

Synthesis of polysubstituted isoquinolines through cross-coupling reactions with α-alkoxytosylhydrazones

A Pd-catalyzed cross-coupling reaction of α-alkoxytosylhydrazones with sulfonates derived from salicyl aldehydes gives rise to protected 1,5-dicarbonyl compounds. Treatment with ammonium hydroxide readily transforms these alkenes into isoquinolines with d