1373829-87-8

Basic information

• Product Name: (S)-1,7-di(pyridine-3-yl)heptane-4-yl 1-(3,5-dichloro-4-hydroxyphenylsulfonyl) piperidine-2-carboxylate
• Synonyms: (S)-1,7-di(pyridine-3-yl)heptane-4-yl 1-(3,5-dichloro-4-hydroxyphenylsulfonyl) piperidine-2-carboxylate
• CAS NO: 1373829-87-8
• Molecular Weight: 606.57
• Mol File: 1373829-87-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1,7-di(pyridine-3-yl)heptane-4-yl 1-(3,5-dichloro-4-hydroxyphenylsulfonyl) piperidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1,7-di(pyridine-3-yl)heptane-4-yl 1-(3,5-dichloro-4-hydroxyphenylsulfonyl) piperidine-2-carboxylate(1373829-87-8)
• EPA Substance Registry System: (S)-1,7-di(pyridine-3-yl)heptane-4-yl 1-(3,5-dichloro-4-hydroxyphenylsulfonyl) piperidine-2-carboxylate(1373829-87-8)

Safety Data

• Hazardous Substances Data: 1373829-87-8(Hazardous Substances Data)

Upstream product

• 173186-16-8 (S)-1,7-di(pyridin-3-yl)heptan-4-yl piperidine-2-carboxylate 
• 13432-81-0 3,5-dichloro-4-hydroxybenzene-1-sulfonyl chloride 

Relevant articles and documents

Exploration of pipecolate sulfonamides as binders of the FK506-binding proteins 51 and 52

FK506-binding proteins (FKBP) 51 and 52 are cochaperones that modulate the signal transduction of steroid hormone receptors. Single nucleotide polymorphisms in the gene encoding FKBP51 have been associated with a variety of psychiatric disorders. Rapamycin and FK506 are two macrocyclic natural products, which tightly bind to most FKBP family members, including FKBP51 and FKBP52. A bioisosteric replacement of the α-ketoamide moiety of rapamycin and FK506 with a sulfonamide was envisaged with the retention of the conserved hydrogen bonds. A focused solid support-based synthesis protocol was developed, which led to ligands with submicromolar affinity for FKBP51 and FKBP52. The molecular binding mode for one sulfonamide analogue was confirmed by X-ray crystallography.