1373832-85-9

Basic information

• Product Name: 2-methoxy-N-[1-(4-fluorophenyl)ethyl]acetamide
• Synonyms: 2-methoxy-N-[1-(4-fluorophenyl)ethyl]acetamide
• CAS NO: 1373832-85-9
• Molecular Weight: 211.236
• Mol File: 1373832-85-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-methoxy-N-[1-(4-fluorophenyl)ethyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-N-[1-(4-fluorophenyl)ethyl]acetamide(1373832-85-9)
• EPA Substance Registry System: 2-methoxy-N-[1-(4-fluorophenyl)ethyl]acetamide(1373832-85-9)

Safety Data

• Hazardous Substances Data: 1373832-85-9(Hazardous Substances Data)

Upstream product

• 3938-96-3 ethyl 2-methoxyacetate 
• 403-40-7 1-(4-fluorophenyl)ethylamine 
• 17640-21-0 isopropyl methoxyacetate 

Relevant articles and documents

Solvent-free kinetic resolution of primary amines catalyzed by Candida antarctica lipase B: Effect of immobilization and recycling stability

Highly enantioselective (E >200) N-acylation of nine racemic primary amines with isopropyl methoxyacetate in the presence of Candida antarctica lipase B (Novozym 435) has been reported to yield the unreacted (S)-amines (ee ≥98%) and produced the (R)-amides (ee ≥95%) at 50% conversion under solvent-free conditions. One of the amines and the acyl donor have been used in an equimolar ratio at room temperature (23 °C). Under the reaction conditions, the reuse stability of Novozym 435 with 1-phenylethylamine (as a model compound) has been shown to be poor while somewhat improved stability has been observed with an in-house prepared sol-gel CAL-B catalyst.

Chemoenzymatic Dynamic Kinetic Resolution of Primary Benzylic Amines using Pd0-CalB CLEA as a Biohybrid Catalyst

Herein, we report on the use a biohybrid catalyst consisting of palladium nanoparticles immobilized on cross-linked enzyme aggregates of lipase B of Candida antarctica (CalB CLEA) for the dynamic kinetic resolution (DKR) of benzylic amines. A set of amines were demonstrated to undergo an efficient DKR and the recyclability of the catalysts was studied. Extensive efforts to further elucidate the structure of the catalyst are presented.