137384-48-6 Usage
Uses
Used in Pharmaceutical Industry:
6-Chloro-3-Methyl-imidazo[1,2-B]Pyridazine is used as a building block for the synthesis of pharmaceutical compounds due to its potential antifungal and antitumor activities. Its incorporation into drug molecules can enhance their therapeutic effects against various diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 6-Chloro-3-Methyl-imidazo[1,2-B]Pyridazine is utilized as a key intermediate in the development of agrochemicals, contributing to the creation of effective products for pest and disease control in agriculture.
Used in Photodynamic Therapy:
6-Chloro-3-Methyl-imidazo[1,2-B]Pyridazine is being investigated for its potential as a photosensitizer in photodynamic therapy. Its ability to absorb light and generate reactive oxygen species makes it a candidate for the treatment of various conditions, including cancer and bacterial infections.
Used in Research and Development:
CMIP serves as a versatile intermediate in the research and development of new bioactive molecules. Its unique structure and reactivity make it a promising candidate for the discovery of novel compounds with potential applications in medicine, agriculture, and other fields.
Check Digit Verification of cas no
The CAS Registry Mumber 137384-48-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,3,8 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 137384-48:
(8*1)+(7*3)+(6*7)+(5*3)+(4*8)+(3*4)+(2*4)+(1*8)=146
146 % 10 = 6
So 137384-48-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H6ClN3/c1-5-4-9-7-3-2-6(8)10-11(5)7/h2-4H,1H3
137384-48-6Relevant academic research and scientific papers
INHIBITORS OF LIN28 AND METHODS OF USE THEREOF
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Page/Page column 52; 56-57, (2021/06/26)
The present disclosure relates to compounds of formula (I) and compositions comprising the same. The disclosure further relates to methods of treating cancers.
Synthetic studies on condensed-azole derivatives. IV. Synthesis and anti-asthmatic activities of ω-sulfamoylalkyloxyimidazo[1,2-b]pyridazines
Kuwahara, Masaaki,Kawano, Yasuhiko,Shimazu, Hiroshi,Ashida, Yasuko,Miyake, Akio
, p. 122 - 131 (2007/10/03)
A series of novel (imidazo[1,2-b]pyridazin-6-yl)oxyalkylsulfonamides was synthesized and evaluated for the ability to inhibit platelet activating factor (PAF)-induced bronchoconstriction in guinea pigs. The compounds bearing a gem-dialkyl or a cycloalkylidene group at the 2 position of the sulfamoylpropyloxy group in the side chain were found to have potent activity. Among them, 3-(imidazo[1,2-b]pyridazin-6-yl)oxy-2,2-dimethylpropanesulfonamide (6) showed excellent anti-asthmatic activity and the longest duration of action. The compounds bearing a methyl group at the 7 or 8 position of the imidazo[1,2-b]pyridazine ring were found to have enhanced activity. Among them, 3-(7-methylimidazo[1,2-b]pyridazin-6-yl)oxy-2,2-dimethylpropanesulfonamide (25) showed the most potent inhibitory effect, and its anti-asthmatic effect in an experimental model of allergic asthma was superior to that of theophylline. The structure-activity relationships in this series of compounds are discussed.
