1373887-64-9

Upstream product

• 1373887-67-2 C₁₅H₁₁ClN₂O₂ 
• 2894-45-3 (2-aminophenyl)(2-chlorophenyl)methanone 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 1373887-13-8 azepan-1-yl[4-(2-chlorophenyl)quinazolin-2-yl]methanone 
• 1373887-28-5 (S)-N-sec-butyl-4-(2-chlorophenyl)-N-methylquinazoline-2-carboxamide 
• 1373887-29-6 (R)-N-5-sec-butyl-4-(2-chlorophenyl)-N-methylquinazolin-2-carboxamide 
• 1373887-54-7 (S)-N-sec-butyl-4-(2-chlorophenyl)quinazoline-2-carboxamide 
• 1373887-55-8 (R)-N-sec-butyl-4-(2-chlorophenyl)quinazoline-2-carboxamide 
• 1373887-59-2 4-(2-chlorophenyl)-N-isobutylquinazoline-2-carboxamide 
• 1581275-40-2 N-benzyl-4-(2-chlorophenyl)-N-ethylquinazoline-2-carboxamide 
• 1581275-71-9 4-(2-chlorophenyl)-N-(4-methylbenzyl)quinazoline-2-carboxamide 
• 1581275-61-7 N-benzyl-4-(2-chlorophenyl)quinazoline-2-carboxamide 
• 1581275-55-9 N-benzyl-4-(2-chlorophenyl)-N-methylquinazoline-2-carboxamide 
• 1581275-52-6 4-(2-chlorophenyl)-N-ethyl-N-(4-methylbenzyl)quinazoline-2-carboxamide 

Relevant academic research and scientific papers

Exploiting the 4-Phenylquinazoline Scaffold for the Development of High Affinity Fluorescent Probes for the Translocator Protein (TSPO)

The quinazoline class was exploited to search for a new translocator protein (TSPO) fluorescent probe endowed with improved affinity and residence time (RT). Computational studies on an "in-house" collection of quinazoline derivatives, featuring highly st

Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors

Structure-activity relationships (SARs) within the 4-phenylquinazoline-2- carboxamide series of translocator protein (TSPO) ligands have been explored further by the synthesis and TSPO binding affinity evaluation of N-benzyl-N-ethyl/methyl derivatives var

Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein

A series of novel 4-phenylquinazoline-2-carboxamides (1-58) were designed as aza-isosters of PK11195, the well-known 18 kDa translocator protein (TSPO) reference ligand, and synthesized by means of a very simple and efficient procedure. A number of these derivatives bind to the TSPO with Ki values in the nanomolar/subnanomolar range, show selectivity toward the central benzodiazepine receptor (BzR) and exhibit structure-affinity relationships consistent with a previously published pharmacophore/topological model of ligand-TSPO interaction.