1373919-81-3

Basic information

• Product Name: (S)-3-[(S)-hydroxy(phenyl)methyl]-5,7-dimethoxy-3H-isobenzofuran-1-one
• Synonyms: (S)-3-[(S)-hydroxy(phenyl)methyl]-5,7-dimethoxy-3H-isobenzofuran-1-one
• CAS NO: 1373919-81-3
• Molecular Weight: 300.311
• Mol File: 1373919-81-3.mol

Chemical Properties

• CAS DataBase Reference: (S)-3-[(S)-hydroxy(phenyl)methyl]-5,7-dimethoxy-3H-isobenzofuran-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-[(S)-hydroxy(phenyl)methyl]-5,7-dimethoxy-3H-isobenzofuran-1-one(1373919-81-3)
• EPA Substance Registry System: (S)-3-[(S)-hydroxy(phenyl)methyl]-5,7-dimethoxy-3H-isobenzofuran-1-one(1373919-81-3)

Safety Data

• Hazardous Substances Data: 1373919-81-3(Hazardous Substances Data)

Downstream Products

• 1373919-78-8 (+)-matteucen C 

Relevant articles and documents

CN-assisted oxidative cyclization of cyano cinnamates and styrene derivatives: A facile entry to 3-substituted chiral phthalides

The asymmetric dihydroxylation (AD) of o-cyano cinnamates and styrene derivatives leads to efficient construction of chiral phthalide frameworks in high optical purities. This unique reaction is characterized by unusual synergism between CN and osmate groups resulting in rate enhancement of the AD process. The method is amply demonstrated by the synthesis and the structural/stereochemical assignment of the natural products.

A SINGLE STEP ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED CHIRAL PHTHALIDES

The present invention discloses single step, highly enantioselective catalytic oxidative cyclization process for the synthesis of 3-substituted chiral phthalides. In particular, the invention discloses asymmetric synthesis of chiral phthalides via synergetic nitrile accelerated oxidative cyclization of o-cyano substituted aryl alkenes in high yield and enantiomeric excess (ee) in short reaction time. Also, disclosed herein is "one -pot" asymmetric synthesis of biologically important natural compounds having 3-substituted chiral phthalide structural framework in the molecule.