1373922-87-2Relevant academic research and scientific papers
Metal-free regioselective C-H amination for the synthesis of pyrazole-containing 2H-indazoles
Wang, Kai,Wei, Tingting,Zhang, Yujia,Hou, Jiahao,Bai, Renren,Xie, Yuanyuan
, p. 1787 - 1794 (2021)
A general and practical regioselective approach for the C-H amination of 2H-indazoles under transition-metal-free conditions was developed. A series of substrates were tested showing eminent functional group tolerance and affording the C-N functionalization products in good to excellent yields. Mechanism studies revealed that a radical process was involved in this transformation.
A Facile One-Step Synthesis of 2-Arylindazoles via Reductive Cyclization of N-(2-nitroarylidene)amines
Lin, Wei,Hu, Minghua,Feng, Xian,Cao, Chengpao,Huang, Zhibin,Shi, Daqing
, p. 1170 - 1174 (2015/08/06)
A mild and efficient synthesis of 2-arylindazole derivatives via the reductive cyclization of nitro-aryl substrates mediated by a low-valent titanium reagent (TiCl4/Sm/Et3N) has been developed. The attractive features of the current method include an N-N bond formation and the selective reduction of the =C-N bond and nitro group, both of which were easily achieved in one-pot by controlling the pH of the reaction mixture.
An efficient synthesis of 2H-indazoles via reductive cyclization of 2-nitrobenzylamines induced by low-valent titanium reagent
Sun, Fang,Feng, Xian,Zhao, Xuan,Huang, Zhi-Bin,Shi, Da-Qing
experimental part, p. 3851 - 3855 (2012/06/30)
An efficient and improved synthesis of 2H-indazoles via reductive cyclization of 2-nitrobenzylamines induced by low-valent titanium reagent (TiCl4/Zn) is described. In this reaction triethylamine (TEA) was used to control the pH value. This met
