1373927-61-7Relevant academic research and scientific papers
Enantioselective synthesis of optically active cis-β-thio-α- amino acid derivatives through an organocatalytic cascade thio-Michael/ring opening process
Geng, Zhi-Cong,Li, Ning,Chen, Jian,Huang, Xiao-Fei,Wu, Bin,Liu, Guo-Gui,Wang, Xing-Wang
supporting information; experimental part, p. 4713 - 4715 (2012/06/01)
Non-naturally enantioenriched cis-β-thio-α-amino acid derivatives were synthesized through one pot, cascade thio-Michael/ring opening reaction of aromatic thiols with (Z)-olefinic azlactones in good yields with high levels of diastereoselectivities and enantioselectivities, which was catalyzed by a chiral bifunctional thiourea-tertiary amine catalyst.
