137394-67-3Relevant academic research and scientific papers
New applications of PhI(OAc)2 in synthesis: Total synthesis and SAR development of potent antitumor natural product psymberin/irciniastatin A
Shao, Ning,Huang, Xianhai,Palani, Anandan,Aslanian, Robert,Buevich, Alexei,Piwinski, John,Huryk, Robert,Seidel-Dugan, Cynthia
scheme or table, p. 2855 - 2872 (2010/03/05)
A novel PhI(OAc)2-mediated oxidative cyclization reaction is discovered for the synthesis of a-oxy N-acyl aminals and hemiaminals in good yields from readily synthesized N-acyl enamines. This methodology represents a cascade process to construct the core structure of the pederin family of natural products. The total synthesis of psymberin, a member of the pederin family, is accomplished using this ring-closure reaction as the key step. This new method is further showcased in the preparation of advanced psymberin analogues. The biological data of these analogues are presented. Georg Thieme Verlag Stuttgart.
