1374003-49-2Relevant academic research and scientific papers
One-step catalytic enantioselective α-quaternary 5-hydroxyproline synthesis: An asymmetric entry to highly functionalized α-quaternary proline derivatives
Breistein, Palle,Johansson, Jonas,Ibrahem, Ismail,Lin, Shuangzheng,Deiana, Luca,Sun, Junliang,Cordova, Armando
, p. 1156 - 1162 (2012/05/20)
The highly enantioselective cascade reaction between N-protected α-cyanoglycine esters and α,β-unsaturated aldehydes is disclosed. The reaction represents a one-step entry to polysubstituted 5-hydroxyproline derivatives having a quaternary α-stereocenter generally in high yields with up to >95:5 dr and 99:1 er. It is also a direct catalytic two-step entry to functionalized α-quaternary proline derivatives.
