1374016-49-5Relevant academic research and scientific papers
Iodine(III)-mediated intermolecular allylic amination under metal-free conditions
Souto, Jose A.,Zian, Debora,Muniz, Kilian
, p. 7242 - 7245 (2012)
A new approach to direct intermolecular allylic amination has been developed using metal-free conditions at room temperature. The reaction employs a hypervalent iodine(III) reagent as an oxidant and bistosylimide as a nitrogen source. A series of different allylic aminations are presented with up to a 99% yield. Mechanistic studies including isotope labeling and Hammett correlation suggest that depending on the substrate structure two different mechanisms can be operating.
