1374025-87-2Relevant academic research and scientific papers
Reductive N -alkylation of nitroarenes: A green approach for the N-alkylation of natural products
Wahba, Amir E.,Hamann, Mark T.
experimental part, p. 4578 - 4585 (2012/06/30)
A simple, mild, cost-effective, and green approach for the reductive mono-N-alkylation of nitroarenes has been developed. HOAc/Zn are utilized as the reducing system together with a carbonyl compound as an alkyl source in methanol. Excellent yields were obtained with stoichiometric control of mono- over dialkylated products. Application to five complex natural products demonstrated the practical utility of the method.
