1374030-19-9

Usage

Uses

Used in Pharmaceutical Industry:
(11bS)-4-Hydroxy-2,6-bis(4-methoxyphenyl)-4-oxidedinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin is used as a potential pharmaceutical agent for its unique molecular structure and potential interactions with biological systems. Its complex arrangement of naphthalene, phenyl groups, and the phosphorus-containing dioxaphosphepin ring may offer novel therapeutic opportunities, such as targeting specific biological pathways or interacting with cellular components in innovative ways.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (11bS)-4-Hydroxy-2,6-bis(4-methoxyphenyl)-4-oxidedinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin serves as a subject of study for understanding its chemical properties, reactivity, and potential as a lead compound in drug discovery. Its intricate structure may provide insights into the design of new pharmaceuticals with improved efficacy and selectivity.

Upstream product

• 1199631-29-2 (R)-(+)-3,3'-bis(4-methoxyphenyl)-[1,1'-binaphthalene]-2,2'-diol 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 189518-78-3 (Ra)-3,3’-diiodo-2,2’-bis(methoxymethoxy)-1,1’-binaphthalene 
• 18531-94-7 (R)-1,1'-Bi-2-naphthol 

Relevant academic research and scientific papers

Hypercrosslinking chiral Br?nsted acids into porous organic polymers for efficient heterogeneous asymmetric organosynthesis

Here, we developed a construction strategy for directly immobilizing the axially chiral phosphoric acid into hypercrosslinked polymers by a one-pot Friedel-Crafts alkylation reaction. The obtained chiral polymers have high porosity, excellent stability and tailorable catalytic centers, and display excellent activity, enantioselectivity and recyclability for asymmetric transfer hydrogenation.

Chiral Bronsted acid catalyzed enantioselective Mannich-type reaction

Mannich-type reaction of ketene silyl acetals with aldimines proceeded catalytically by means of a phosphoric acid diester, derived from (R)-BINOL, as a chiral Bronsted acid to afford β-amino esters with good diastereoselectivity in favor of the syn isomer and high enantioselectivity (up to 96% ee). The highest enantioselectivity was achieved by the phosphoric acid diester bearing 4-nitrophenyl groups on the 3,3′-positions of BINOL. The N-2-hydroxyphenyl group of aldimine was found to be essential for the present Mannich-type reaction. In combination with these experimental investigations, two possible monocoordination and dicoordination pathways were explored using density functional theory calculations (BHandHLYP/6-31G*). The present reaction proceeds via a dicoordination pathway through the zwitterionic and nine-membered cyclic transition state (TS) consisting of the aldimine and the phosphoric acid. The re-facial selectivity was also well-rationalized theoretically. The nine-membered cyclic structure and aromatic stacking interaction between the 4-nitrophenyl group and N-aryl group would fix the geometry of aldimine on the transition state, and the si-facial attacking TS is less favored by the steric hindrance of the 3,3′-aryl substituents.

ASYMMETRIC-SYNTHESIS CATALYST BASED ON CHIRAL BROENSTED ACID AND METHOD OF ASYMMETRIC SYNTHESIS WITH THE CATALYST

A compound usable as an asymmetric synthesis catalyst which can be easily synthesized without using any metal such as a lanthanoid group element; a method of asymmetric synthesis with the compound; and a chiral compound obtained by the asymmetric synthesis method. A Broensted acid is used as a catalyst in asymmetric synthesis, the chiral Broensted acid being represented by formula (1) below or formula (3) below. The asymmetric synthesis method employs the catalyst. Asymmetric synthesis with the catalyst gives a chiral compound.

Enantioselective direct aza hetero-Diels-Alder reaction catalyzed by chiral Bronsted acids

(Chemical Equation Presented) The first chiral Bronsted acid-catalyzed asymmetric direct aza hetero-Diels-Alder reaction has been described. The phosphoric acids, prepared from binol and H8-binol derivatives, have shown catalytic ability for th