1374034-49-7Relevant academic research and scientific papers
Highly efficient catalytic asymmetric Sulfa-Michael addition of thiols to trans-4,4,4-trifluorocrotonoylpyrazole
Dong, Xiu-Qin,Fang, Xin,Tao, Hai-Yan,Zhou, Xiang,Wang, Chun-Jiang
supporting information; experimental part, p. 1141 - 1147 (2012/05/20)
A new protocol for the efficient construction of chiral trifluoromethylated building blocks was developed via organocatalyzed sulfa-Michael addition of thiols to the cost-efficient trans-trifluorocrotonamide. Introducing the pyrazole moiety is crucial to providing H-bond acceptor sites for better activation and hence affording comparable asymmetric induction with that obtained when employing the expensive cis-4,4,4-trifluorocrotonate as the Michael acceptor. Copyright
