137406-84-9Relevant academic research and scientific papers
Kinetic Evidence for the Occurrence of Kinetically Detectable Intermediates in the Cleavage of N-Ethoxy-carbonylphthalimide under N-Methylhydroxylamine Buffers
Khan, N. Niyaz
, p. 95 - 103 (2002)
The kinetics of the aqueous cleavage of N-ethoxycarbonylphthalimide (NCPH) in CH3NHOH buffers of different pH reveals that the cleavage follows the general irreversible consecutive reaction path NCPH(k1obs) -> ENMBC(k2obs) -> A(k3obs) -> B, where ENMBC, A, and B represent ethyl N-[o-(N-methyl-N-hydroxycarbamoyl)benzoyl]carbamate, N-hydroxyl group cyclized product of ENMBC, and o-(N-methyl-N-hydroxycarbamoyl)benzoic acid, respectively. The rate constant k1obs at a constant pH, obeys the relationship k1obs = kw + knapp [Am]T + kb[Am]T2, where [Am]T is the total concentration of CH3NHOH buffer and kw is first-order rate constant for pH-independent hydrolysis of NCPH. Buffer-dependent rate constant kb shows the presence of both general base and general acid catalysis. Both the rate constants k2obs and k3obs are independent of [Am]T (within the [Am]T range of present study) at a constant pH and increase linearly with the increase in αOH with definite intercepts.
