1374123-99-5

Basic information

• Product Name: CP-281-F₁
• Synonyms: CP-281-F₁
• CAS NO: 1374123-99-5
• Molecular Weight: 357.406
• Mol File: 1374123-99-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: CP-281-F₁(CAS DataBase Reference)
• NIST Chemistry Reference: CP-281-F₁(1374123-99-5)
• EPA Substance Registry System: CP-281-F₁(1374123-99-5)

Safety Data

• Hazardous Substances Data: 1374123-99-5(Hazardous Substances Data)

Upstream product

• 94-62-2 Piperine 
• 50838-22-7 1-crotonoylpiperidine 
• 108-24-7 acetic anhydride 

Relevant articles and documents

Quorum sensing and nf-κb inhibition of synthetic coumaperine derivatives from piper nigrum

Bacterial communication, termed Quorum Sensing (QS), is a promising target for virulence attenuation and the treatment of bacterial infections. Infections cause inflammation, a process regulated by a number of cellular factors, including the transcription Nuclear Factor kappa B (NF-κB); this factor is found to be upregulated in many inflammatory diseases, including those induced by bacterial infection. In this study, we tested 32 synthetic derivatives of coumaperine (CP), a known natural compound found in pepper (Piper nigrum), for Quorum Sensing Inhibition (QSI) and NF-κB inhibitory activities. Of the compounds tested, seven were found to have high QSI activity, three inhibited bacterial growth and five inhibited NF-κB. In addition, some of the CP compounds were active in more than one test. For example, compounds CP-286, CP-215 and CP-158 were not cytotoxic, inhibited NF-κB activation and QS but did not show antibacterial activity. CP-154 inhibited QS, decreased NF-κB activation and inhibited bacterial growth. Our results indicate that these synthetic molecules may provide a basis for further development of novel therapeutic agents against bacterial infections.