1374137-41-3

Upstream product

• 6089-09-4 4-pentynoic acid 
• 6541-41-9 all-trans-β-apo-8'-Carotenol 
• 1107-26-2 trans-β-apo-8'-carotenal 

Downstream Products

• 1374137-47-9 C₄₂H₅₃N₃O₂ 

Relevant academic research and scientific papers

Synthesis of carotenoid-monosaccharide conjugates via azide–alkyne click-reaction

Carotenoid pentynoates were coupled to protected and unprotected sugar azides via an azide-alkyne click-reaction using bis-triphenylphosphano-copper(I)-butyrate (C3H7COOCu(PPh3)2) complex. Protected sugars delivered the conjugates with excellent yields, whereas with unprotected ones amphipathic carotenoid-sugar derivatives were obtained in good or moderate yields in a simple way.

Introduction of click chemistry to carotenoids

We describe the synthesis of carotenoid derivatives via the azide-alkyne click reaction and optimize the conditions for these sensitive molecules. After finding the mildest conditions possible for the reaction we were able to use the click reaction for the synthesis of PEG-carotenoid conjugates starting from carotenoid pentynoates and PEG azides.