1374137-63-9Relevant academic research and scientific papers
Design, synthesis and structure-activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists
Lainé, Dramane I.,Yan, Hongxing,Xie, Haibo,Davis, Roderick S.,Dufour, Jeremy,Widdowson, Katherine L.,Palovich, Michael R.,Wan, Zehong,Foley, James J.,Schmidt, Dulcie B.,Hunsberger, Gerald E.,Burman, Miriam,Bacon, Alicia M.,Webb, Edward F.,Luttmann, Mark A.,Salmon, Michael,Sarau, Henry M.,Umbrecht, Sandra T.,Landis, Philip S.,Peck, Brian J.,Busch-Petersen, Jakob
scheme or table, p. 3366 - 3369 (2012/06/18)
A novel series of N-substituted tropane derivatives was characterized as potent muscarinic acetylcholine receptor antagonists (mAChRs). Kinetic washout studies showed that the N-endosubstituted analog 24 displayed much slower reversibility at mAChRs than
