1374151-64-0

Basic information

• Product Name: 2-benzyl-4-hydroxy-1-oxa-7-azacyclotetradecane-6,14-dione
• Synonyms: 2-benzyl-4-hydroxy-1-oxa-7-azacyclotetradecane-6,14-dione
• CAS NO: 1374151-64-0
• Molecular Weight: 333.428
• Mol File: 1374151-64-0.mol

Chemical Properties

• CAS DataBase Reference: 2-benzyl-4-hydroxy-1-oxa-7-azacyclotetradecane-6,14-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-4-hydroxy-1-oxa-7-azacyclotetradecane-6,14-dione(1374151-64-0)
• EPA Substance Registry System: 2-benzyl-4-hydroxy-1-oxa-7-azacyclotetradecane-6,14-dione(1374151-64-0)

Safety Data

• Hazardous Substances Data: 1374151-64-0(Hazardous Substances Data)

Upstream product

• 1374151-53-7 tert-butyldimethyl((R)-1-((R)-oxiran-2-yl)-3-phenylpropan-2-yloxy)silane 
• 1374151-69-5 (4S,6R)-6-(tert-butyldimethylsilyloxy)-7-phenylhept-1-en-4-ol 
• 122332-14-3 (S)-1-phenylpent-4-en-2-ol 
• 929-17-9 7-aminoheptanoic acid 
• 17994-94-4 methyl 7-aminoheptanoate hydrochloride 
• 122-78-1 phenylacetaldehyde 
• 1374151-71-9 S-2-acetamidoethyl 7-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-6-phenylhexanamido)heptanethioate 
• 1374151-70-8 methyl 7-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-6-phenylhexanamido)heptanoate 

Relevant articles and documents

6-Deoxyerythronolide B synthase thioesterase-catalyzed macrocyclization is highly stereoselective

Macrocyclic polyketide natural products are an indispensable source of therapeutic agents. The final stage of their biosynthesis, macrocyclization, is catalyzed regio- and stereoselectively by a thioesterase. A panel of substrates were synthesized to test their specificity for macrocyclization by the erythromycin polyketide synthase TE (DEBS TE) in vitro. It was shown that DEBS TE is highly stereospecific, successfully macrocyclizing a 14-member ring substrate with an R configured O-nucleophile, and highly regioselective, generating exclusively the 14-member lactone over the 12-member lactone.