137418-50-9Relevant academic research and scientific papers
SYNTHESIS OF A NEW TYPE OF ANTIOXIDANT POSSESSING INHIBITORY ACTIVITY AGAINST HMG-CoA REDUCTASE
Matsumoto, Masakatsu,Watanabe, Nobuko,Mori, Eiko,Aoyama, Misao,Kusunoki, Jun,Yamaura, Tetsuaki
, p. 2589 - 2592 (1994)
The 6-hydroxychromans (4) and (6), and 5-hydroxy-2,3-dihydrobenzofurans (5) and (7) bearing a 4-hydroxypyran-2-one moiety were synthesized.All the compounds exhibited potent activity against lipid peroxidation.The chroman (4) possessed inhibitory activ
4-Hydroxytetrahydropyran-2-one derivatives
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, (2008/06/13)
4-hydroxytetrahydropyran-2-one derivatives with general formula (I) are useful as cholesterol reducing agents as well as lipid reducing agents, serving as inhibitors of HMG-CoA reductase, and capable of inhibiting the biosynthesis of peroxidized lipids, and therefore effective for curing arteriosclerosis: STR1 wherein R1 represent hydrogen or a 2-tetrahydropyranyl group; R2 and R3 each represent hydrogen or an alkyl group having 1 to 6 carbon atoms; R4 represents hydrogen, an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, an aryl group, an aralkyl group, an acyl group, an aroyl group or a substituted sulfonyl group; A represents --CH2 CH2 --, or --CH=CH--; and n is an integer of 1 or 2, and intermediates for synthesizing the 4-hydroxytetrahydropyran-2-one derivatives are disclosed.
