137419-00-2Relevant academic research and scientific papers
Orally Active, Nonpeptide Oxytocin Antagonists
Evans, Ben E.,Leighton, James L.,Rittle, Kenneth E.,Gilbert, Kevin F.,Lundell, George F.,et al.
, p. 3919 - 3927 (2007/10/02)
The first nonpeptide antagonists of the neurohypophyseal hormone, oxytocin (OT) are described.Derivatives of the spiroindenepiperidine ring system, these compounds include L-366,509, an orally bioavailable OT antagonist with good in vivo duration.The potential use of these agents for treatment of preterm labor and their significance as new nonpeptide ligands for peptide receptors are discussed.
SPIROCYCLIC OXYTOCIN ANTAGONISTS
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, (2008/06/13)
Disclosed are spirocyclic compounds of the formula: STR1 The compounds of formula I are oxytocin antagonists useful in the treatment of preterm labor and dysmenorrhea, and for the stoppage of labor preporatory to Caesarian delivery. Also disclosed are pharmaceutical compositions containing these compounds as well as methods for preparing the compounds.
