1374218-52-6

Basic information

• Product Name: 5,6,7,4'-tetraacetoxy-8-iodoflavone
• CAS NO: 1374218-52-6
• Molecular Weight: 580.286
• Mol File: 1374218-52-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,6,7,4'-tetraacetoxy-8-iodoflavone(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,4'-tetraacetoxy-8-iodoflavone(1374218-52-6)
• EPA Substance Registry System: 5,6,7,4'-tetraacetoxy-8-iodoflavone(1374218-52-6)

Safety Data

• Hazardous Substances Data: 1374218-52-6(Hazardous Substances Data)

Upstream product

• 27740-01-8 scutellarin 
• 21967-41-9 baicalin 
• 1180-46-7 4,5,6,7-tetra-O-acetylflavone 
• 108-24-7 acetic anhydride 

Relevant articles and documents

Synthesis and biological evaluation of 8-substituted and deglucuronidated scutellarin and baicalin analogues as antioxidant responsive element activators

Flavonoids are important bioactive dietary compounds, which are proved to be antioxidant responsive element (ARE) activators to defend against electrophilic toxicants and oxidative stress. The activators induce ARE gene transcription through Nrf2 factor, a major transcriptional stimulator of cytoprotective genes, relieved from a Keap1 complex. In this report, based on the structures of two flavonoids, scutellarin and baicalin, which are extracted from two common Chinese plants Dengzhanhua (Erigeron breviscapus (vant) Hand-Mazz) and Huangqin (Scutellaria baicalensis Georigi), respectively, we synthesized several 8-substituted and deglucuronidated analogues and identified the ARE activation effects of these flavonoids. We found that the Baicalin, deglucurnonidated Baicalin and diaza cyclopenta derivative were more active. Their dose-dependent upregulation activities of ARE and NQO1 and induction effects of Nrf2 were testified. The results presented that these three analogues had good upregulation effects on ARE, and they could be potentially utilized in relieving oxidative stress, upon further neuroprotective tests.