1374227-89-0Relevant academic research and scientific papers
Palladium-catalyzed regioselective 5-exo-o-cyclization/oxidative Heck cascades from o-alkynylbenzamides and electron-deficient alkenes
Madich, Youssef,álvarez, Rosana,Aurrecoechea, José M.
, p. 6263 - 6271 (2014)
A Pd-catalyzed 5-exo-selective oxycyclization/oxidative Heck coupling cascade is described, starting from readily available ortho-alkynylbenzamides and functionalized olefins. The key to a high regioselectivity in the cyclization step is the choice of catalyst and/or additives. Thus, Pd(OAc)2 provides the desired 5-exo products predominantly, whereas with PdCl2 or Pd(TFA)2, the corresponding 6-endo products prevail. The subsequent oxidative Heck-type coupling takes place stereoselectively with the very predominant formation of E isomers, leading to an effective preparation of structurally diverse carbonyl-substituted allylideneisobenzofuranimines.
A practical protocol for three-component, one-pot, stepwise sonogashira-heterocyclization-heck couplings
Madich, Youssef,Denis, J.Gabriel,Ortega, Aitor,Martinez, Claudio,Matrane, Abdellatif,Belachemi, Larbi,De Lera, Angel R.,Alvarez, Rosana,Aurrecoechea, Jose M.
, p. 2009 - 2017 (2013/07/26)
A three-component, one-pot, stepwise Sonogashira-heterocyclization-Heck- coupling process was developed starting from either haloarenecarboxamides, halophenols or haloanilines, terminal alkynes and electron-deficient alkenes. Cyclic imidate-, benzofuran-,
