1374248-83-5

Upstream product

• 1455358-16-3 (S)-1‘-(tert-butyl)-2’-oxo-1‘,2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3’-pyrrolo[2,3-b]pyridine]-3-carboxylic acid 
• 1455358-05-0 5-chloro-3-(((tetrahydro-2H-pyrana-2-yl)oxy)methyl)picolinaldehyde 
• 1227585-65-0 (2-bromo-5-chloropyridin-3-yl)methanol 
• 137628-17-2 2,3-dibromo-5-chloro-pyridine 
• 1260403-56-2 methyl tert-butyl(3-methylpyridin-2-yl)carbamate 
• 1235305-63-1 N-(tert-butyl)-3-methylpyridin-2-amine 
• 1455358-36-7 C₁₃H₁₆N₂O₃ 
• 1455358-14-1 (S)-1'-(tert-butyl)-3-chloro-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one 
• 1455358-12-9 1-(tert-butyl)-3-((5-chloro-3-(chloromethyl)pyridin-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one 
• 1456804-09-3 C₂₃H₂₈ClN₃O₃ 
• 1455358-11-8 1-(tert-butyl)-3-((5-chloro-3-(hydroxymethyl)pyridin-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one 
• 1455358-09-4 (E)-1-(tert-butyl)-3-((5-chloro-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)pyridin-2-yl)methylene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one 
• 1455358-06-1 1-(tert-butyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one 

Relevant academic research and scientific papers

Process for Making CGRP Receptor Antagonists

The invention encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, which are CGRP receptor antagonists useful for the treatment of migraine.

PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS

The disclosure encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, having less steps and improved yields as compared to previous synthetic methods for making these compounds, which are CGRP receptor antagonists, useful for the treatment of migrane. Conditions for an amide bond formation between an acid and amine include for example reacting the compounds of Formulae B (after salt break) and C with an amide coupling reagent and optionally an additive and an acid and/or a base in a non-reactive solvent.