1374250-22-2

Upstream product

• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 645-45-4 hydrocinnamic acid chloride 
• 140-10-3 (E)-3-phenylacrylic acid 
• 102-92-1 Cinnamoyl chloride 

Downstream Products

• 1352050-90-8 (E)-3-phenyl-1-(4-(E)-3-[4-(trifluoromethyl)phenyl]-2-propenoylpiperazino)-2-propen-1-one 
• 1352050-91-9 (E)-3-phenyl-1-(4-(E)-3-[3-(trifluoromethoxy)phenyl]-2-propenoylpiperazino)-2-propen-1-one 
• 1352050-92-0 (E)-3-(4-fluorophenyl)-1-4-[(E)-3-phenyl-2-propenoyl]piperazino-2-propen-1-one 
• 1352050-93-1 (E)-3-(4-chlorophenyl)-1-4-[(E)-3-phenyl-2-propenoyl]piperazino-2-propen-1-one 
• 1352050-94-2 (E)-3-(4-bromophenyl)-1-4-[(E)-3-phenyl-2-propenoyl]piperazino-2-propen-1-one 
• 1352050-95-3 (E)-3-(3,4-difluorophenyl)-1-4-[(E)-3-phenyl-2-propenoyl]piperazino-2-propen-1-one 
• 1352050-96-4 (E)-3-(3,4-dichlorophenyl)-1-4-[(E)-3-phenyl-2-propenoyl]piperazino-2-propen-1-one 
• 1352050-97-5 (E)-3-(4-hydroxy-3-methoxyphenyl)-1-4-[(E)-3-phenyl-2-propenoyl]piperazino-2-propen-1-one 
• 20087-96-1 (E)-3-phenyl-1-4-[(E)-3-phenyl-2-propenoyl]piperazino-2-propen-1-one 
• 84935-37-5 (E)-3-phenyl-1-(piperazin-1-yl)prop-2-en-1-one 

Relevant academic research and scientific papers

Synthesis, evaluation, and molecular properties prediction of substituted cinnamoylpiperazine derivatives as potential antinociceptive and anticonvulsive agents

A series of novel cinnamoylpiperazine derivatives (5a–5l) were synthesized as potential antinociceptive, and anticonvulsive agents. Various heterocyclic systems like piperidine, morpholine, piperazine, and N-arylpiperazine were combined with cinnamoyl or methylenedioxy cinnamoyl moieties to obtain a series of constrained analogs of cinnamides. Of these, compound 5e possessing 4-fluorophenyl substitution on the piperazine ring exhibited good antinociceptive activity in capsaicin and formalin-induced nociception methods, and also significant anticonvulsant activity in pentylenetetrazole and maximal electroshock-induced seizure methods. Further, all the derivatives were studied for molecular and preadmet properties. The activities of compound 5e were supported by molecular and preadmet properties for its in silico oral bioavailability and drug-likeness.

Amide α,β-Dehydrogenation Using Allyl-Palladium Catalysis and a Hindered Monodentate Anilide

A practical and direct method for the α,β-dehydrogenation of amides is reported using allyl-palladium catalysis. Critical to the success of this process was the synthesis and application of a novel lithium N-cyclohexyl anilide (LiCyan). The reaction conditions tolerate a wide variety of substrates, including those with acidic heteroatom nucleophiles.

Synthesis of cinnamide dimers as potential antibacterial and antifungal agents

A series of new cinnamide dimers was synthesized (5a-6a) and evaluated for th e i r antimicrobial and antifungal activity. All the compounds investigated have shown significant antimicrobial a c t iv i ty against gram-positive and gram-negative bacterial