137426-78-9Relevant articles and documents
Chloro-oxime derivatives as novel small molecule chaperone amplifiers
Zhou, Yuefen,Vu, Khang,Chen, Yongsheng,Pham, John,Brady, Thomas,Liu, Gang,Chen, Jinhua,Nam, Joonwoo,Murali Mohan Reddy,Au, Qingyan,Yoon, Il Sang,Tremblay, Marie-Helene,Yip, Gary,Cher, Charmian,Zhang, Bin,Barber, Jack R.,Ng, Shi Chung
, p. 3128 - 3135 (2009)
Chloro-oxime derivatives were investigated as novel small molecule chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC50 10 μM).