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[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol, also known as TMPB-OPh-OH, is a boronic acid derivative that plays a significant role in organic synthesis and medicinal chemistry. It features a distinctive structure with a boron atom attached to a phenyl ring and a hydroxyl group, which makes it particularly useful for cross-coupling reactions and as a component in the construction of pharmaceutical compounds. This chemical is recognized for its stability, compatibility with a wide range of functional groups, and its capacity to create robust bonds with other organic molecules, positioning it as an indispensable resource for professionals in drug discovery and development.

1374294-47-9

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1374294-47-9 Usage

Uses

Used in Organic Synthesis:
[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol is used as a reagent in organic synthesis for its ability to participate in cross-coupling reactions, facilitating the formation of carbon-carbon bonds and enhancing the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, [2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol is utilized as a building block for the development of pharmaceutical compounds. Its unique structure allows for the creation of new molecules with potential therapeutic properties, contributing to the advancement of drug discovery.
Used in Drug Discovery and Development:
[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol is employed as a key intermediate in the synthesis of novel drug candidates. Its stability and compatibility with various functional groups make it an ideal component for the design and synthesis of new pharmaceutical entities, potentially leading to the discovery of innovative treatments for various diseases and conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 1374294-47-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,4,2,9 and 4 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1374294-47:
(9*1)+(8*3)+(7*7)+(6*4)+(5*2)+(4*9)+(3*4)+(2*4)+(1*7)=179
179 % 10 = 9
So 1374294-47-9 is a valid CAS Registry Number.

1374294-47-9Relevant academic research and scientific papers

Transition-metal-free, one-pot synthesis of benzoxaboroles from: O -bromobenzaldehydes via visible-light-promoted borylation

Chen, Jianchao,Hu, Yanjun,Jia, Xingxing,Luo, Jinghan,Sun, Tiemin

, p. 10455 - 10459 (2021/12/17)

A novel and simple one-pot stepwise method to synthesize benzoxaboroles was demonstrated. This step-by-step synthetic method includes photocatalytic boronization with phenothiazine as a photocatalyst and sequential water-induced reduction in the presence of bis(pinacolato)diboron. A series of o-bromobenzaldehydes were well-tolerated under the standard conditions. In addition, this method has been successfully applied in the synthesis of the anti-tuberculosis candidate drug GSK 3036656 and anti-fungal drug tavaborole. This journal is

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