1374342-09-2

Upstream product

• 769944-79-8 4-(4-bromophenyl)piperidine hydrogen chloride salt 
• 6226-25-1 2,2,2-trifluoroethyl trifluoromethanesulphonate 

Downstream Products

• 1374339-36-2 1-(6-(4-chloro-4'-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-[1,1'-biphenyl]-2-yl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 
• 1374342-52-5 4-[4'-methyl-2'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl-4-yl]-1-(2,2,2-trifluoroethyl)piperidine 
• 1374342-53-6 2-bromo-6-{4-methyl-4'-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridine 
• 1374342-54-7 2-fluoro-6-{4-methyl-4'-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridine 
• 1374341-65-7 1-(6-{4-methyl-4'-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridin-2-yl)azetidine-3-carboxylic acid 
• 1374339-38-4 1-[2'-{4-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]phenyl}-5'-(trifluoromethyl)-2,3'-bipyridin-6-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid trifluoroacetate 
• 1374342-10-5 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-(2,2,2-trifluoroethyl)piperidine 

Relevant academic research and scientific papers

ETHYL N-BOC PIPERIDINYL PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

Provided are compounds of Formula I as JAK inhibitors, which are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

SOLUBLE GUANYLATE CYCLASE ACTIVATORS

This inventions relates to compounds having the structure Formula I and pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.