1374357-72-8

Upstream product

• 154607-01-9 4-bromo-2-chlorobenzonitrile 
• 1374573-05-3 4-allyl-2-chlorobenzonitrile 
• 34841-48-0 (3-chloro-4-cyanophenyl)acetic acid 

Downstream Products

• 1431944-11-4 tert-butyl (2-{[2-(3-chloro-4-cyanophenyl)ethyl]amino}ethyl)carbamate 
• 1431943-61-1 2-chloro-4-(2-{2-oxo-4-[2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}ethyl)benzonitrile 
• 1431944-12-5 tert-butyl (2-{(chloroacetyl)[2-(3-chloro-4-cyanophenyl)ethyl]amino}ethyl)carbamate 
• 1431944-10-3 2-chloro-4-[2-(2-oxopiperazin-1-yl)ethyl]benzonitrile 

Relevant academic research and scientific papers

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

no abstract published

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir 1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.