1374400-41-5

Basic information

• Product Name: N-cyclopropyl-7-hydroxy-5-oxo-2-[(2-oxo-2-phenylethyl)sulfanyl]-4H,5H-thieno[3,2-b]pyridine-3-carboxamide
• CAS NO: 1374400-41-5
• Molecular Weight: 400.479
• Mol File: 1374400-41-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-cyclopropyl-7-hydroxy-5-oxo-2-[(2-oxo-2-phenylethyl)sulfanyl]-4H,5H-thieno[3,2-b]pyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclopropyl-7-hydroxy-5-oxo-2-[(2-oxo-2-phenylethyl)sulfanyl]-4H,5H-thieno[3,2-b]pyridine-3-carboxamide(1374400-41-5)
• EPA Substance Registry System: N-cyclopropyl-7-hydroxy-5-oxo-2-[(2-oxo-2-phenylethyl)sulfanyl]-4H,5H-thieno[3,2-b]pyridine-3-carboxamide(1374400-41-5)

Safety Data

• Hazardous Substances Data: 1374400-41-5(Hazardous Substances Data)

Upstream product

• 70-11-1 α-bromoacetophenone 
• 15029-37-5 2-cyano-N-cyclopropylacetamide 

Relevant articles and documents

New regio-selective method of combinatorial synthesis of substituted thiophenes, thieno[3,2-b]pyridines and other heterocycles via combination of 'domino'-type reactions

We present a novel combinatorial multicomponent regio-selective approach towards the synthesis of thieno[3,2-b]pyridines and pyridine pyrans. The methodology is based on the 'domino'-type reaction. The high regio-selectivity in this reaction is gained by the in situ generation of the mono-potassium salt of 2-cyano-1-mercaptoethenethiolate. We also demonstrate that the use of ethyl 2-cyanoacetate in this reaction as a CH-acid leads to the termination of the domino sequence at the Dieckmann condensation step and yields novel ethyl 3-(4-cyano-3-hydroxy-5-(alkylthio)thiophen-2-yl)-3-oxopropanoate.