1374404-41-7Relevant academic research and scientific papers
Application of phosphine-nitrogen ligands and complexes thereof in catalysis of asymmetric reactions
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, (2021/10/27)
The invention relates to application of phosphine-nitrogen ligands and complexes thereof in catalysis of asymmetric reactions. The phosphine-nitrogen ligands contain at least one of structures shown in general formulas (I) and (II). The phosphine-nitrogen ligands provided by the invention can be used for preparing the complexes. The prepared complexes can be used as a catalyst for catalytic synthesis of enol lactone compounds containing chiral carbon; and reactions catalyzed by the complexes have the characteristics of high regioselectivity and enantioselectivity, high reaction efficiency and the like.
Pd(ii)-SDP-catalyzed enantioselective 5-exo-dig cyclization of γ-alkynoic acids: Application to the synthesis of functionalized dihydofuran-2(3H)-ones containing a chiral quaternary carbon center
Sridharan, Vellaisamy,Fan, Lulu,Takizawa, Shinobu,Suzuki, Takeyuki,Sasai, Hiroaki
, p. 5936 - 5943 (2013/09/12)
The Pd(ii)-SDP-catalyzed first enantioselective intramolecular cyclization of α,α-disubstituted γ-alkynoic acids is described. This 5-exo-dig cyclization afforded dihydrofuran-2(3H)-ones bearing a chiral quaternary carbon center in excellent yields with e
Enantioselective, desymmetrizing bromolactonization of alkynes
Wilking, Michael,Mueck-Lichtenfeld, Christian,Daniliuc, Constantin G.,Hennecke, Ulrich
supporting information, p. 8133 - 8136 (2013/07/05)
Asymmetric bromolactonizations of alkynes are possible using a desymmetrization approach. The commercially available catalyst (DHQD) 2PHAL promotes these cyclizations in combination with cheap NBS as a bromine source to give bromoenol lactones in high yield and with high enantioselectivity. The bromoenol lactone products, containing a tetrasubstituted alkene and a quaternary stereocenter, are valuable building blocks for synthetic chemistry.
Cycloisomerization versus hydration reactions in aqueous media: A Au(III)-NHC catalyst that makes the difference
Tomas-Mendivil, Eder,Toullec, Patrick Y.,Diez, Josefina,Conejero, Salvador,Michelet, Veronique,Cadierno, Victorio
supporting information; experimental part, p. 2520 - 2523 (2012/07/14)
A novel water-soluble Au(III)-NHC complex has been synthesized and successfully applied in the intramolecular cyclization of γ-alkynoic acids into enol-lactones under biphasic toluene/water conditions, thus representing a rare example of an active and sel
