1374418-24-2Relevant academic research and scientific papers
Fluorescent nucleosides with 'on-off' switching function, pH-responsive fluorescent uridine derivatives
Saito, Yoshio,Miyamoto, Shigenori,Suzuki, Azusa,Matsumoto, Katsuhiko,Ishihara, Tsutomu,Saito, Isao
scheme or table, p. 2753 - 2756 (2012/05/19)
We synthesized various pH-responsive fluorescent deoxyuridine derivatives (1a-g). These fluorescent nucleosides exhibited distinctive fluorescence at 470-600 nm in aqueous solvents containing methanol only at acidic to neutral pH values. In particular, 1f exhibited strong fluorescence only at pH range of 3.1-7.2 with a pKa of 6.1. Such pH-sensitive fluorescent nucleosides can be used as 'on-off' fluorescence switch for monitoring pH change in biological systems, particularly for cancer cell detection.
