1374418-91-3Relevant academic research and scientific papers
An N-heterocyclic carbene/lewis acid strategy for the stereoselective synthesis of spirooxindole lactones
Dugal-Tessier, Julien,O'Bryan, Elizabeth A.,Schroeder, Thomas B. H.,Cohen, Daniel T.,Scheidt, Karl A.
, p. 4963 - 4967 (2012)
A cooperative catalysis approach for the enantioselective formal [3+2] addition of α,β-unsaturated aldehydes to isatins has been developed. Homoenolate annulations of β-aryl enals catalyzed by an N-heterocyclic carbene (NHC) require the addition of lithium chloride for high levels of enantioselectivity. This NHC-catalyzed annulation has been used for the total synthesis of maremycin B. Copyright
Dinuclear zinc catalyzed asymmetric spirannulation reaction: An umpolung strategy for formation of α-alkylated-α-hydroxyoxindoles
Trost, Barry M.,Hirano, Keiichi
, p. 2446 - 2449 (2012/07/27)
A highly diastereo- and enantioselective formal [3 + 2] cycloaddition of α,β-unsaturated esters and 3-hydroxyoxindoles catalyzed by a dinuclear zinc-ProPhenol complex is reported. The stereoselective Michael additions of 3-hydroxyoxindoles and the subsequent transesterifications afford spirocyclic δ-lactones.
