1374419-55-2Relevant academic research and scientific papers
Total synthesis of indolizidine (+)-223A
Fellah, Mouloud,Lhommet, Gerard,Mouries-Mansuy, Virginie
supporting information; experimental part, p. 463 - 465 (2012/03/10)
We described the diastereoselective total synthesis of indolizidine (+)-223A in 10% overall yield over 14 steps starting from 6-chlorohex-2-ynoate. Our strategy involved chain elongation through aldolization, the formation of the indolizidine skeleton by cyclization, and stereocontrolled hydrogenation. We described the diastereoselective total synthesis of indolizidine (+)-223A in 10% overall yield over 14 steps starting from 6-chlorohex-2-ynoate. The influence of theN-protecting group of the starting pyrrolidine to form the indolizidine skeleton was studied. Copyright
