1374422-09-9Relevant articles and documents
Solvent-free stereoselective organocatalyzed aldol reaction of 2-hydroxycyclobutanone
Aitken, David J.,Capitta, Francesca,Frongia, Angelo,Ollivier, Jean,Piras, Pier Paolo,Secci, Francesco
experimental part, p. 727 - 730 (2012/07/02)
The stereoselective solvent-free organocatalyzed aldol reaction of 2-hydroxycyclobutanone with a selection of aromatic aldehydes has been investigated. Using l-threonine (20 mol%), deracemized aldol adducts featuring a chiral quaternary center were obtained in yields up to 72%, with syn selectivity up to 85:15 and ee up to 84%. The title compound has markedly superior reactivity to other α-hydroxy ketones. Georg Thieme Verlag Stuttgart · New York.