1374450-41-5

Upstream product

• 87-41-2 2-benzofuran-1(3H)-one 
• 1374450-16-4 (R)-tert-Butyl 1-((S)-(benzyloxycarbonylamino)(p-tolyl)methyl)-3-oxo-1,3-dihydroisobenzofuran-1-carboxylate 
• 1374450-07-3 tert-butyl 3-oxo-1,3-dihydroisobenzofuran-1-carboxylate 
• 129881-51-2 acid chloride of 1-oxo-1,3-dihydroisobenzofuran-3-carboxylic acid 

Downstream Products

• 1374450-42-6 (3S,4R)-4-hydroxy-4-(hydroxymethyl)-3-p-tolyl-3,4-dihydroisoquinolin-1(2H)-one 
• 1374450-43-7 (3S,4R)-4-(hydroxymethyl)-3-p-tolyl-1,2,3,4-tetrahydroisoquinolin-4-ol 

Relevant academic research and scientific papers

Direct asymmetric Mannich reaction of phthalides: Facile access to chiral substituted isoquinolines and isoquinolinones

The first Mannich reaction employing phthalides using a quinidine-based multifunctional catalyst has been developed. The reported method led to the synthesis of 3,3-disubstituted phthalide derivatives in excellent yields, with good diastereo- and enantioselectivities. Convenient synthesis of chiral isoquinolinones and isoquinolines has also been demonstrated.