137447-15-5Relevant academic research and scientific papers
Nickel-Catalyzed Aerobic Oxidative Isocyanide Insertion: Access to Benzimidazoquinazoline Derivatives via a Sequential Double Annulation Cascade (SDAC) Strategy
Shinde, Anand H.,Arepally, Sagar,Baravkar, Mayur D.,Sharada, Duddu S.
, p. 331 - 342 (2017)
An efficient protocol for the synthesis of quinazoline derivatives through nickel-catalyzed ligand-/base-free oxidative isocyanide insertion under aerobic conditions with intramolecular bis-amine nucleophiles has been developed. A one-pot sequential double annulation cascade (SDAC) strategy involving an opening of isatoic anhydride and annulation to benzimidazole and further nickel-catalyzed intramolecular isocyanide insertion has also been demonstrated. The method is operationally simple to implement with a wide variety of substrates and represents a new approach for multiple C-N bond formations. The methodology has been successfully applied to the syntheses of hitherto unreported imidazo-fused benzimidazoquinazolines via a deprotection-GBB reaction sequence. Further, a florescence study reveals the potential of the present strategy for the discovery of highly fluorescent probes.
Synthesis of benzodiazepinoperimidine - A new heterocycle
Reddy, V Rama Kishan,Reddy, P S N,Ratnam, C V
, p. 927 - 931 (2007/10/02)
Reaction of 2-(2-aminophenyl)perimidines (3) with chloroacetyl chlorides leads to benzodiazepinoperimidin-6(7H)-ones (5) while reaction with oxalyl chloride leads to the corresponding 6,7-diones (10).Quinazolinoperimidin-6(5H)-ones (4)
