1374507-50-2Relevant academic research and scientific papers
A second-generation total synthesis of spirastrellolide A methyl ester
Paterson, Ian,Maltas, Philip,Dalby, Stephen M.,Lim, Jong Ho,Anderson, Edward A.
supporting information; experimental part, p. 2749 - 2753 (2012/04/17)
Marine macrolides: An improved second-generation total synthesis of the anticancer macrolide spirastrellolide A methyl ester has been achieved. The synthesis features a uniformly high level of stereocontrol combined with more expedient fragment assembly, and demonstrates a critical dependence of the crucial macrolactonization step on the substitution pattern of the C22-C24 linker region. Copyright
