1374516-34-3

Upstream product

• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 
• 98-80-6 phenylboronic acid 
• 857276-61-0 5-fluoro-2-bromobenzyl chloride 

Downstream Products

• 1374516-05-8 3-(4-((4-fluoro-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid 

Relevant academic research and scientific papers

GPR120 RECEPTOR MODULATORS

There is provided novel 4-fluoro-phenyl-methoxy-benzene carboxylic acid compounds (insert formula I) capable of modulating the G-protein-coupled receptor GPR120, which can be used for controlling insulin levels in vivo and for the treatment of conditions such as type II diabetes, hypertension, ketoacidosis, obesity, glucose intolerance, and hypercholesterolemia and related disorders associated with abnormally high or low plasma lipoprotein, triglyceride or glucose levels. Also claimed are the compounds for use in the treatment of obesity, type II diabetes and metabolic syndrome.

Discovery of a potent and selective GPR120 agonist

GPR120 is a receptor of unsaturated long-chain fatty acids reported to mediate GLP-1 secretion, insulin sensitization, anti-inflammatory, and anti-obesity effects and is therefore emerging as a new potential target for treatment of type 2 diabetes and metabolic diseases. Further investigation is however hindered by the lack of suitable receptor modulators. Screening of FFA1 ligands provided a lead with moderate activity on GPR120 and moderate selectivity over FFA1. Optimization led to the discovery of the first potent and selective GPR120 agonist.